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The underlying active mechanisms of change generation, which enable efficient adaptive evolution, have eluded biologists for decades. Until now...

The prevailing scientific view still holds that organismal and cancer evolution is largely a function of accumulated random genetic mutations and natural selection.

While inefficient random mutations were the primary mechanism of evolution during early life on Earth that still play a prominent role in pathobiology...

in the modern era of biology, genomic adaptive change generation prior to Darwinian selection is primarily the result of feedback-driven, active cell biology processes.

Evolution of Our Universe and Planet, and the Origins of Life and Meaning